消化性溃疡疾病中的内源性前列腺素
Endogenous prostaglandins in peptic ulcer disease.
作者信息
Baker R, Jaffe B M, Venables C W
出版信息
Gut. 1979 May;20(5):394-9. doi: 10.1136/gut.20.5.394.
Abstract
Plasma concentrations of prostaglandins E and F have been measured by radioimmunoassay in patients undergoing diagnostic upper intestinal endoscopy. The results fail to support a previously reported deficiency of plasma PGE in duodenal ulcer patients. Plasma prostaglandin concentrations failed to correlate with the parameters of gastric secretion studied; and were unaffected by histamine H2-receptor blockade or the activity of duodenal ulceration. During combined pentagastrin and insulin secretory studies there was a significant correlation between the outputs of PGE and acid into gastric juice.
摘要
采用放射免疫分析法测定了接受诊断性上消化道内镜检查患者的血浆前列腺素E和F浓度。结果不支持先前报道的十二指肠溃疡患者血浆PGE缺乏。血浆前列腺素浓度与所研究的胃液分泌参数无关；且不受组胺H2受体阻断或十二指肠溃疡活动的影响。在联合五肽胃泌素和胰岛素分泌研究期间，PGE分泌量与胃液中酸分泌量之间存在显著相关性。
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