猫体内的内源性前列腺素与胃液分泌
Endogenous prostaglandins and gastric secretion in the cat.
作者信息
Baker R, Jaffe B M, Reed J D, Shaw B, Venables C W
出版信息
J Physiol. 1978 May;278:451-60. doi: 10.1113/jphysiol.1978.sp012316.
Abstract
- The gastric juice outputs of acid, pepsin, PGE and PGF, and the plasma concentrations of PGE and PGF have been measured in response to I.V. infusions of pentagastrin, histamine and insulin in the conscious cat. 2. There were significant correlations between the output of gastric acid and gastric outputs of both PGE and PGF during secretion produced by all stimulants. Furthermore, there were similar significant correlations between the gastric outputs of pepsin and both PGE and PGF. However, during insulin stimulation there was significantly more pepsin output per unit PGE or PGF output than during either pentagastrin or histamine stimulation. 3. The correlations between the outputs of gastric acid and both PGE and PGF were similar during pentagastrin and insulin stimulation whereas those between acid and PGE and PGF altered during the infusion of histamine. 4. It is concluded that these data partially, but not entirely, support the hypothesis that local release of prostaglandins may act as a negative feed-back mechanism on gastric acid secretion. 5. Plasma prostaglandin concentration did not correlate with changes in acid or pepsin secretion.
摘要
- 已对清醒猫静脉输注五肽胃泌素、组胺和胰岛素后，测量了胃酸、胃蛋白酶、前列腺素E（PGE）和前列腺素F（PGF）的胃液分泌量，以及血浆中PGE和PGF的浓度。2. 在所有刺激物引起的分泌过程中，胃酸分泌量与PGE和PGF的胃液分泌量之间均存在显著相关性。此外，胃蛋白酶的胃液分泌量与PGE和PGF之间也存在类似的显著相关性。然而，在胰岛素刺激期间，每单位PGE或PGF分泌量产生的胃蛋白酶分泌量显著多于五肽胃泌素或组胺刺激期间。3. 在五肽胃泌素和胰岛素刺激期间，胃酸分泌量与PGE和PGF之间的相关性相似，而在组胺输注期间，胃酸与PGE和PGF之间的相关性发生了变化。4. 得出的结论是，这些数据部分但并非完全支持前列腺素的局部释放可能作为胃酸分泌的负反馈机制这一假说。5. 血浆前列腺素浓度与胃酸或胃蛋白酶分泌的变化无关。
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