口服阿莫西林和氨苄西林的比较临床药理学
Comparative clinical pharmacology of amoxicillin and ampicillin administered orally.
作者信息
Gordon C, Regamey C, Kirby W M
出版信息
Antimicrob Agents Chemother. 1972 Jun;1(6):504-7. doi: 10.1128/AAC.1.6.504.
Abstract
Ampicillin and amoxicillin (alpha-amino-p-hydroxybenzyl penicillin) were administered orally in 500-mg doses to eight fasting volunteers in a comparative study in which pharmacokinetic techniques were used. The absorption of amoxicillin was significantly better, as demonstrated by a higher mean peak serum concentration of 7.6 mug/ml as compared to 3.2 mug/ml for ampicillin, an average "area under the curve" that was approximately double that of ampicillin, and an 8-hr urinary recovery for amoxicillin of 60% as compared to 34% for ampicillin. Serum half-lives were the same for the two antibiotics, with values of 60.3 (+/-3.3) min for ampicillin and 61.3 (+/-5.6) min for amoxicillin. The latter drug gave measurable concentrations in the blood at 8 hr in all of eight volunteers, as compared to only three of eight with ampicillin.
摘要
在一项采用药代动力学技术的对比研究中，给8名空腹志愿者口服500毫克剂量的氨苄西林和阿莫西林（α-氨基-对羟基苄青霉素）。阿莫西林的吸收明显更好，表现为平均血清峰值浓度更高，阿莫西林为7.6微克/毫升，而氨苄西林为3.2微克/毫升；平均“曲线下面积”约为氨苄西林的两倍；阿莫西林8小时尿回收率为60%，而氨苄西林为34%。两种抗生素的血清半衰期相同，氨苄西林为60.3（±3.3）分钟，阿莫西林为61.3（±5.6）分钟。8名志愿者服用阿莫西林后8小时血液中均可测得药物浓度，而服用氨苄西林的8名志愿者中只有3人在8小时后血液中可测得药物浓度。
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