Haase-Aschoff K, Lingens F
Hoppe Seylers Z Physiol Chem. 1979 May;360(5):621-32.
A bacterium growing on papaverine as sole carbon and nitrogen source was isolated by incubation of soil with papaverine. The bacterium could be identified as a Nocardia strain by morphological and physiological tests. When growing on papaverine, this strain excretes metabolites into the medium. Based on the structure of the metabolites 1--9 a degradation pathway is proposed. 1 = 1-(3,4-Dimethoxybenzyl)-3,4-dihydro-6,7-dimethoxy-3,4-isoquinolinediol; 2 = 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-3,4-isoquinolinediol; 3 = 2-(3,4-dimethoxyphenyl)-1-[2-(2-hydroxyethyl)-4,5-dimethoxyphenly]ethanone; 4 = 2-hydroxy-4,5-dimethoxybenzeneethanol; 5 = 3,4-dimethoxybenzeneacetic acid; 6 = 2-hydroxy-4,5-dimethyoxybenzeneacetic acid; 7 = 4-hydroxy-3-methoxybenzeneacetic acid; 8 = 3,4-dimethoxybenzaldehyde; 9 = 2-(hydroxymethyl)-4,5-dimethoxybenzeneethanol.
通过将土壤与罂粟碱一起培养，分离出一种以罂粟碱作为唯一碳源和氮源生长的细菌。通过形态学和生理学测试，该细菌可被鉴定为诺卡氏菌属菌株。当在罂粟碱上生长时，该菌株会向培养基中分泌代谢产物。基于代谢产物1 - 9的结构，提出了一条降解途径。1 = 1-(3,4-二甲氧基苄基)-3,4-二氢-6,7-二甲氧基-3,4-异喹啉二醇；2 = 1-(3,4-二甲氧基苄基)-6,7-二甲氧基-3,4-异喹啉二醇；3 = 2-(3,4-二甲氧基苯基)-1-[2-(2-羟乙基)-4,5-二甲氧基苯基]乙酮；4 = 2-羟基-4,5-二甲氧基苯乙醇；5 = 3,4-二甲氧基苯乙酸；6 = 2-羟基-4,5-二甲氧基苯乙酸；7 = 4-羟基-3-甲氧基苯乙酸；8 = 3,4-二甲氧基苯甲醛；9 = 2-(羟甲基)-4,5-二甲氧基苯乙醇。
