Hauer B, Lingens F
Hoppe Seylers Z Physiol Chem. 1982 May;363(5):507-13. doi: 10.1515/bchm2.1982.363.1.507.
Tryptophan catabolism was studied in a papaverine-degrading Nocardia sp. L-Tryptophan degradation follows the quinoline route via kynurenic acid. 5-(2-Carboxyethyl)-4,6-dihydroxypicolinic acid was isolated as a kynurenic acid metabolite. Mutants were induced with N-methyl-N'-nitro-N-nitrosoguanidine. A mutant was isolated, which accumulated 5-hydroxyanthranilic acid. There is no relationship between kynurenic acid degradation and papaverine degradation. All kynurenic acid mutants were able to use papaverine as a carbon source and all papaverine mutants could be grown at the expense of kynurenic acid.
在一株可降解罂粟碱的诺卡氏菌属菌株中研究了色氨酸分解代谢。L-色氨酸通过犬尿酸途径沿喹啉路线降解。5-(2-羧乙基)-4,6-二羟基吡啶甲酸作为犬尿酸的代谢产物被分离出来。用N-甲基-N'-硝基-N-亚硝基胍诱导突变体。分离出一个积累5-羟基邻氨基苯甲酸的突变体。犬尿酸降解与罂粟碱降解之间没有关系。所有犬尿酸突变体都能够利用罂粟碱作为碳源，并且所有罂粟碱突变体都能够以犬尿酸为代价生长。
