Badraoui M H, Bonnar J, Hillier K, Embrey M P
Br Med J. 1973 Jan 6;1(5844):19-21. doi: 10.1136/bmj.1.5844.19.
Serial studies on coagulation factors were performed on 12 patients having termination of mid-trimester pregnancy by extra-amniotic prostaglandin F(2)alpha and 11 patients terminated by vacuum aspiration during the first trimester. A significant change in the activity of factors V, VII and X, VIII, and X, and a decrease of the prothrombin time and platelet count were found with prostaglandin termination but no such changes occurred during vacuum aspiration. These findings suggest that the coagulation system is activated during induction of mid-trimester abortion with extra-amniotic prostaglandin F(2)alpha. This is probably related to the physiological changes in the coagulation mechanism which occur by the second trimester of pregnancy. Termination of pregnancy in the mid-trimester may, however, be expected to give rise to defective blood coagulation and thromboembolic complications.
对12例通过羊膜外前列腺素F(2)α终止中期妊娠的患者和11例在孕早期通过真空吸引终止妊娠的患者进行了凝血因子的系列研究。发现使用前列腺素终止妊娠时，因子V、VII和X、VIII以及X的活性有显著变化，凝血酶原时间和血小板计数降低，但在真空吸引过程中未发生此类变化。这些发现表明，在使用羊膜外前列腺素F(2)α诱导中期流产期间，凝血系统被激活。这可能与妊娠中期发生的凝血机制的生理变化有关。然而，中期妊娠终止可能会导致凝血功能缺陷和血栓栓塞并发症。
