Kaumeier S
Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):260-3.
The present investigation is concerned with the influence of the composition of food on the absorption of sulfameter. Six physically healthy patients each were given 2 g of sulfameter simultaneously with a high lipid, high protein and high carbohydrate test meal. This experiment was designed as a threefold crossover study, and there was a randomized assignment of patients to the different conditions. The results show that sulfameter is significantly better absorbed when administered with a high lipid meal than when given with a high protein or high carbohydrate meal, demonstrated by the areas under the serum concentration curves (AUC), by the peak serum concentration and by the cumulative renal excretion.
本研究关注食物成分对磺胺米隆吸收的影响。六名身体健康的患者每人同时服用2克磺胺米隆，并搭配高脂、高蛋白和高碳水化合物测试餐。本实验设计为三重交叉研究，患者被随机分配到不同条件下。结果表明，与高脂餐同时服用时，磺胺米隆的吸收明显优于与高蛋白或高碳水化合物餐同时服用，这通过血清浓度曲线下面积（AUC）、血清峰值浓度和累积肾排泄量得以证明。
