Kaumeier H S
Arzneimittelforschung. 1980;30(10):1794-800.
It is demonstrated that the bioavailability of sulfamethoxydiazine (Durenat), taken as an example, is much better when administered simultaneously with a test meal than when given in the fasting state. Also a high-lipid meal in comparison with a high-protein or high-carbohydrate meal considerably improves the bioavailability of sulfamethoxydiazone. Food as well as the composition of food are likely to have short-term and long-term consequences on absorption and biotransformation and therefore influence the bioavailability of drugs.
以磺胺二甲嘧啶（Durénat）为例，已证明与试验餐同时服用时，其生物利用度比空腹服用时要好得多。此外，与高蛋白或高碳水化合物餐相比，高脂餐能显著提高磺胺二甲嘧啶的生物利用度。食物以及食物的成分可能会对吸收和生物转化产生短期和长期影响，从而影响药物的生物利用度。
