[The influence of food on the bioavailability of drugs on the example of sulfamethoxydiazine (author's transl)].

It is demonstrated that the bioavailability of sulfamethoxydiazine (Durenat), taken as an example, is much better when administered simultaneously with a test meal than when given in the fasting state. Also a high-lipid meal in comparison with a high-protein or high-carbohydrate meal considerably improves the bioavailability of sulfamethoxydiazone. Food as well as the composition of food are likely to have short-term and long-term consequences on absorption and biotransformation and therefore influence the bioavailability of drugs.