Hambleton G, Appleyard W J
Arch Dis Child. 1973 Jan;48(1):31-5. doi: 10.1136/adc.48.1.31.
A controlled trial of fresh frozen plasma in asphyxiated newborn infants weighing less than 2·5 kg is reported, together with coagulation and other data obtained from the infants. The findings based on 66 infants were as as follows. (1) There was no evidence that infusion of fresh frozen plasma prevented intraventricular haemorrhage. (2) Thrombotest did not appear to be a useful discriminant test for `at risk' infants. (3) Asphyxiated low birthweight infants do not respond to vitamin K in respect of thrombotest or prothrombin time. (4) The initial coagulation status of small-for-dates infants could not be distinguished from normal premature infants.
本文报道了一项针对体重小于2.5千克的窒息新生儿的新鲜冷冻血浆对照试验,并给出了从这些婴儿身上获得的凝血及其他数据。基于66名婴儿的研究结果如下:(1)没有证据表明输注新鲜冷冻血浆可预防脑室内出血。(2)凝血试验似乎并非“高危”婴儿的有效鉴别试验。(3)窒息的低体重婴儿在凝血试验或凝血酶原时间方面对维生素K无反应。(4)小样儿的初始凝血状态与正常早产儿无法区分。