Beverley D W, Chance G W, Inwood M J, Schaus M, O'Keefe B
Arch Dis Child. 1984 May;59(5):444-8. doi: 10.1136/adc.59.5.444.
Twenty five of 106 preterm infants of 34 weeks' gestation or less developed intraventricular haemorrhage within the first 48 hours of life. A comparison of infants with and without intraventricular haemorrhage showed no significant differences in their haemostatic parameters at birth. At age 48 hours the group with intraventricular haemorrhage showed a prolonged activated partial thromboplastin time and reduced factor II, VII, and X activity. There was a significant correlation between the severity of intraventricular haemorrhage and the degree of haemostasis abnormality both in cord blood and in blood obtained at age 48 hours. Those infants sustaining grade IV intraventricular haemorrhage had a significantly prolonged activated partial thromboplastin time, reduced factor II, VII, and X activity; and a decreased fibrinogen concentration at birth. At age 48 hours these defects were accompanied by reduced platelet counts and an increased megathrombocyte index. Although intraventricular haemorrhage is multifactorial, we postulate that correction of haemostasis abnormalities at birth may prevent progression to more severe grades of haemorrhage.
106名孕周34周及以下的早产儿中，有25名在出生后的头48小时内发生了脑室内出血。对有和没有脑室内出血的婴儿进行比较发现，他们出生时的止血参数没有显著差异。在48小时时，发生脑室内出血的组显示活化部分凝血活酶时间延长，因子II、VII和X活性降低。脑室内出血的严重程度与脐带血和48小时时采集的血液中的止血异常程度之间存在显著相关性。那些发生IV级脑室内出血的婴儿出生时活化部分凝血活酶时间显著延长，因子II、VII和X活性降低，纤维蛋白原浓度降低。在48小时时，这些缺陷伴有血小板计数减少和巨型血小板指数增加。虽然脑室内出血是多因素的，但我们推测出生时纠正止血异常可能会防止出血进展到更严重的等级。
