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运动肢体的神经传入在运动性通气过度中的作用。

Role of neural afferents from working limbs in exercise hyperpnea.

作者信息

Weissman M L, Whipp B J, Huntsman D J, Wasserman K

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1980 Aug;49(2):239-48. doi: 10.1152/jappl.1980.49.2.239.

Abstract

To determine the role of reflex discharge of afferent nerves from the working limbs in the exercise hyperpnea, 1.5- to 2.5-min periods of phasic hindlimb muscle contraction were induced in anesthetized cats by bilateral electrical stimulation of ventral roots L7, S1, and S2. Expired minute ventilation (VE) and end-tidal PCO2 (PETCO2) were computed breath by breath, and mean arterial PCO2 (PaCO2) was determined from discrete blood samples and, also in most animals, by continuous measurement with an indwelling PCO2 electrode. During exercise VE rose progressively with a half time averaging approximately 30 s, but a large abrupt increase in breathing at exercise onset typically did not occur. Mean PaCO2 and PETCO2 remained within approximately 1 Torr of control levels across the work-exercise transition, and PaCO2 was regulated at an isocapnic level after VE had achieved its peak value. Sectioning the spinal cord at L1-L2 did not alter these response characteristics. Thus, reflex discharge of afferent nerves from the exercising limbs was not requisite for the matching of ventilation to metabolic demand during exercise.

摘要

为了确定来自工作肢体的传入神经反射性放电在运动性通气过度中的作用,通过双侧电刺激L7、S1和S2腹侧神经根,在麻醉猫身上诱发1.5至2.5分钟的阶段性后肢肌肉收缩。逐次计算呼出气分钟通气量(VE)和呼气末PCO2(PETCO2),并通过离散血样测定平均动脉PCO2(PaCO2),在大多数动物中,还通过留置PCO2电极进行连续测量。运动期间,VE逐渐上升,平均半衰期约为30秒,但运动开始时呼吸通常不会出现大幅突然增加。在从工作到运动的转变过程中,平均PaCO2和PETCO2保持在对照水平约1 Torr范围内,并且在VE达到峰值后,PaCO2被调节在等碳酸水平。在L1-L2水平切断脊髓并没有改变这些反应特征。因此,运动肢体传入神经的反射性放电对于运动期间通气与代谢需求的匹配不是必需的。

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