盐酸两性霉素B甲酯与两性霉素B：急性毒性比较
Amphotericin B methyl ester hydrochloride and amphotericin B: comparative acute toxicity.
作者信息
Keim G R, Poutsiaka J W, Kirpan J, Keysser C H
出版信息
Science. 1973 Feb 9;179(4073):584-5. doi: 10.1126/science.179.4073.584.
PMID:4686465
Abstract
In single-dose parenteral studies with mice and dogs, the methyl ester hydrochloride of amphotericin B proved to be significantly less toxic than the parent compound, especially to the kidney.
摘要
在对小鼠和狗进行的单剂量肠胃外给药研究中，两性霉素B的盐酸甲酯毒性明显低于其母体化合物，尤其是对肾脏的毒性。
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