健康儿童呼吸阻力的频率依赖性

Frequency dependence of respiratory resistance in healthy children.

作者信息

Stănescu D, Moavero N E, Veriter C, Brasseur L

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1979 Aug;47(2):268-72. doi: 10.1152/jappl.1979.47.2.268.

DOI:10.1152/jappl.1979.47.2.268

Abstract

We measured in 130 (61 girls) children aged 3--14 yr respiratory resistance (Rrs), with the oscillation technique, between 4 and 9 Hz. Rrs, at both 4 and 9 Hz, decreased as a function of height (r = 0.74, P less than 0.001). No statistical difference was found between boys and girls. Frequency dependence of resistance (Rrs 4 Hz-Rrs 9 Hz) was found in children at all ages, and decreased with increasing height (r = 0.50, P less than 0.001). We suggest that frequency dependence of resistance in children can be explained on the basis of an increased peripheral resistance, which produces an asynchronous distribution of tidal volume between dead space and lung parenchyma. During growth peripheral resistance decreases and Rrs bcome less frequency dependent to reach at about 15--16 yr independency of frequence.

摘要

我们使用振荡技术，在130名年龄为3至14岁的儿童（61名女孩）中测量了4至9赫兹之间的呼吸阻力（Rrs）。在4赫兹和9赫兹时，Rrs均随身高增加而降低（r = 0.74，P < 0.001）。男孩和女孩之间未发现统计学差异。在所有年龄段的儿童中均发现了阻力的频率依赖性（Rrs 4赫兹 - Rrs 9赫兹），且随身高增加而降低（r = 0.50，P < 0.001）。我们认为，儿童阻力的频率依赖性可以基于外周阻力增加来解释，外周阻力增加会导致潮气量在死腔和肺实质之间的异步分布。在生长过程中，外周阻力降低，Rrs对频率的依赖性降低，在大约15至16岁时达到与频率无关。