Okubo S, Nakamura N, Ito K, Marumo H, Tanaka M, Omura S
J Antibiot (Tokyo). 1979 Apr;32(4):347-54. doi: 10.7164/antibiotics.32.347.
The antifungal antibiotic, prumycin, was studied for antitumor activity against several tumor systems. It was found to possess potential antitumor activity against a well-established mouse mammary adenocarcinoma in C3H/He mice. It was also active in prolongation of the lifespan of mice bearing P-388 lymphocytic leukemia. Moreover, prumycin did not depress the white blood cell counts in the mouse peripheral blood. However, severe alopecia was observed in mice treated with this agent at dosage level near the LD50.
对抗真菌抗生素普鲁霉素针对多种肿瘤系统的抗肿瘤活性进行了研究。发现它对C3H/He小鼠中一种成熟的小鼠乳腺腺癌具有潜在的抗肿瘤活性。它对携带P - 388淋巴细胞白血病的小鼠延长寿命也有活性。此外，普鲁霉素不会降低小鼠外周血中的白细胞计数。然而，在用接近半数致死剂量的该药物处理的小鼠中观察到了严重的脱发。
