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Philosophy of new drug discovery.

作者信息

Omura S

出版信息

Microbiol Rev. 1986 Sep;50(3):259-79. doi: 10.1128/mr.50.3.259-279.1986.

DOI:10.1128/mr.50.3.259-279.1986
PMID:3534537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC373071/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/e5c9c9c80ea9/microrev00054-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/3153c84cd424/microrev00054-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/738f6c671f52/microrev00054-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/f3bb5383a593/microrev00054-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/45d8ce1deff9/microrev00054-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/ece66412d337/microrev00054-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/f0021ecc0e90/microrev00054-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/5aa9a40954b3/microrev00054-0047-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/d26f16262781/microrev00054-0047-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/a6ccfa877c07/microrev00054-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/dd77d7115e87/microrev00054-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/8cf3ac8baa04/microrev00054-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/eec1a0348e16/microrev00054-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/b6bda05d1f07/microrev00054-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/e5c9c9c80ea9/microrev00054-0054-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/3153c84cd424/microrev00054-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/738f6c671f52/microrev00054-0041-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/f3bb5383a593/microrev00054-0042-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/45d8ce1deff9/microrev00054-0044-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/ece66412d337/microrev00054-0045-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/f0021ecc0e90/microrev00054-0047-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/5aa9a40954b3/microrev00054-0047-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/d26f16262781/microrev00054-0047-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/a6ccfa877c07/microrev00054-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/dd77d7115e87/microrev00054-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/8cf3ac8baa04/microrev00054-0049-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/eec1a0348e16/microrev00054-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/b6bda05d1f07/microrev00054-0050-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11be/373071/e5c9c9c80ea9/microrev00054-0054-a.jpg

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本文引用的文献

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[The therapeutic effect of nanaomycin A against experimental Trichophyton mentagrophytes infection in guinea pigs (author's transl)].纳那霉素A对豚鼠实验性须癣毛癣菌感染的治疗作用(作者译)
Jpn J Antibiot. 1980 Jul;33(7):728-32.
2
Stimulation of leucomycin production by magnesium phosphate and its relevance to nitrogen catabolite regulation.磷酸镁对柱晶白霉素产生的刺激作用及其与氮分解代谢调节的相关性。
Antimicrob Agents Chemother. 1980 Nov;18(5):691-5. doi: 10.1128/AAC.18.5.691.
3
A new peptide antibiotic, alboleutin.一种新的肽类抗生素,白蛋白素。
脂磷壁酸菌素,一种报道的首个抑制肽聚糖生物合成移位酶 I 的核苷抗生素:脂磷壁酸菌素及其相关化合物的发现及其在新型抗生素应用上的展望。
J Antibiot (Tokyo). 2019 Dec;72(12):877-889. doi: 10.1038/s41429-019-0241-5. Epub 2019 Oct 4.
4
Rapid analysis of antibiotic-containing mixtures from fermentation broths by using liquid chromatography-electrospray ionization-mass spectrometry and matrix-assisted laser desorption ionization-time-of-flight-mass spectrometry.采用液相色谱-电喷雾电离-质谱和基质辅助激光解吸电离-飞行时间质谱法快速分析发酵液中的含抗生素混合物。
J Am Soc Mass Spectrom. 1996 Dec;7(12):1227-37. doi: 10.1016/S1044-0305(96)00104-3.
5
Bioactive compounds from marine actinomycetes.海洋放线菌中的生物活性化合物。
Indian J Microbiol. 2008 Dec;48(4):410-31. doi: 10.1007/s12088-008-0052-z. Epub 2009 Jan 8.
6
Molecular screening of Streptomyces isolates for antifungal activity and family 19 chitinase enzymes.对链霉菌分离物进行抗真菌活性和 19 家族几丁质酶的分子筛选。
J Microbiol. 2012 Jun;50(3):459-68. doi: 10.1007/s12275-012-2095-4. Epub 2012 Jun 30.
7
Hormesis and a Chemical Raison D'être for Secondary Plant Metabolites.植物次生代谢物的应激效应与化学存在理由
Dose Response. 2010 Apr 23;9(1):79-116. doi: 10.2203/dose-response.09-028.Hadacek.
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A rapid method for screening large numbers of environmental microorganisms for antiviral activity.一种用于筛选大量环境微生物抗病毒活性的快速方法。
Appl Environ Microbiol. 1998 Mar;64(3):1161-2. doi: 10.1128/AEM.64.3.1161-1162.1998.
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Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analyses.异质微生物群体的流式细胞术和细胞分选:单细胞分析的重要性。
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Isolation and characterization of a cytotoxic metabolite of Talaromyces bacillosporus.芽孢瓶霉细胞毒性代谢产物的分离与鉴定
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4
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