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阿片受体:在神经组织中的显示

Opiate receptor: demonstration in nervous tissue.

作者信息

Pert C B, Snyder S H

出版信息

Science. 1973 Mar 9;179(4077):1011-4. doi: 10.1126/science.179.4077.1011.

Abstract

Tritiated naloxone, a powerful opiate antagonist, specifically binds to an opiate receptor of mammalian brain and guinea pig intestine. Competition for the opiate receptor by various opiates and their antagonists closely parallels their pharmacological potency. The opiate receptor is confined to nervous tissue.

摘要

氚标记的纳洛酮是一种强效阿片拮抗剂,它能特异性地与哺乳动物脑和豚鼠肠道的阿片受体结合。各种阿片类药物及其拮抗剂对阿片受体的竞争情况与其药理效力密切平行。阿片受体局限于神经组织。

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