Vesell E S, Lang C M, White W J, Passananti G T, Tripp S L
Science. 1973 Mar 2;179(4076):896-7. doi: 10.1126/science.179.4076.896.
Reduction of aniline hydroxylase activity, ethylmorphine N-dementhylase activity, and cytochrome P-450 content occurred in hepatic microsomes of rats kept under dirty conditions, defined as accumulation for 1 week of urine and feces in pans under the wire mesh cages. In comparison with rats that had urine and feces removed twice daily from such pans, rats kept over Kimpak bedding or over Litter Green, changed twice daily, also showed reduced drug-metabolizing activity in hepatic microsomes, but to a lesser degree than the dirty rats. Placement of a filter top on cages for 1 week also decreased drug-metabolizing activity. These experiments suggest that the relative cleanliness of an animal's environment can influence hepatic microsomal drug metabolism.
在脏污条件下饲养的大鼠肝微粒体中，苯胺羟化酶活性、N-去甲基化乙基吗啡活性以及细胞色素P-450含量降低。脏污条件定义为在金属丝网笼下的托盘中尿液和粪便堆积1周。与每天两次清除托盘中尿液和粪便的大鼠相比，饲养在每天更换两次的Kimpak垫料或Litter Green垫料上的大鼠，其肝微粒体中的药物代谢活性也降低，但程度低于脏污大鼠。在笼子上放置过滤顶盖1周也会降低药物代谢活性。这些实验表明，动物环境的相对清洁程度会影响肝微粒体药物代谢。
