Katz R J, Schmaltz K
Psychopharmacology (Berl). 1979 Sep;65(1):65-8. doi: 10.1007/BF00491980.
In the first experiment, adult male Swiss-Webster mice were systemically injected with a standard dose of morphine. Compared to the influence of vehicle, the motor activity of morphine-injected mice was increased. Neither phenytoin sodium nor carbamazepine alone facilitated motor activity, but pretreatment with both drugs further facilitated the increased motor activity produced by morphine. In a second experiment, mice were injected centrally with a long-acting analog of leu-enkephalin. It also increased motor activity in comparison with vehicle. Again, both phenytoin sodium and carbamazepine further facilitated this response. Both experiments suggest a facilitatory interaction between some aspects of these anticonvulsants and opiate-induced motor activity.
在第一个实验中，对成年雄性瑞士韦伯斯特小鼠全身注射标准剂量的吗啡。与注射赋形剂的影响相比，注射吗啡的小鼠的运动活性增加。苯妥英钠和卡马西平单独使用时均未促进运动活性，但两种药物预处理进一步促进了吗啡引起的运动活性增加。在第二个实验中，向小鼠中枢注射亮脑啡肽的长效类似物。与赋形剂相比，它也增加了运动活性。同样，苯妥英钠和卡马西平均进一步促进了这种反应。两个实验均表明这些抗惊厥药的某些方面与阿片类药物诱导的运动活性之间存在促进性相互作用。
