Can Med Assoc J. 1973 Feb 3;108(3):328-9.
Ontario's program for PKU screening of newborn infants reached 94.5% of the newborn population from 1966 to 1971. There were 70 infants identified by the program, 47 of whom were classical cases and 23 atypical cases of phenylketonuria. The incidence was 1:16,700 live births for classical cases and 1:34,000 live births for atypical cases. Since the beginning of the program 44 children have been identified in infancy as having PKU and have been treated successfully. Retardation has become evident in only three infants, two of whom were missed by the screening program.The cost of identification and care of one child for five years is about $7000, much less than the $250,000 needed to provide lifetime institutional care for one severely retarded individual.
安大略省的新生儿苯丙酮尿症筛查项目在1966年至1971年间覆盖了94.5%的新生儿。该项目共筛查出70名婴儿，其中47例为典型苯丙酮尿症病例，23例为非典型病例。典型病例的发病率为每16,700例活产中有1例，非典型病例的发病率为每34,000例活产中有1例。自该项目启动以来，已有44名儿童在婴儿期被确诊患有苯丙酮尿症并得到了成功治疗。只有三名婴儿出现了智力迟钝的症状，其中两名在筛查项目中被漏检。一名儿童五年的鉴定和护理费用约为7000美元，远低于为一名严重智力迟钝者提供终身机构护理所需的25万美元。
