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庚酸氟奋乃静在晚发性妄想痴呆门诊治疗中的应用

Fluphenazine enanthate in the outpatient treatment of late paraphrenia.

作者信息

Raskind M, Alvarez C, Herlin S

出版信息

J Am Geriatr Soc. 1979 Oct;27(10):459-63. doi: 10.1111/j.1532-5415.1979.tb01727.x.

DOI:10.1111/j.1532-5415.1979.tb01727.x
PMID:469146
Abstract

Fluphenazine enanthate parenterally was compared to an antipsychotic drug (haloperidol) given orally for the "crisis intervention" treatment of elderly outpatients with late paraphrenia. In the fluphenazine group, 11 of 13 patients improved, compared to only 3 of 13 in the oral drug group (p less than 0.01). The superiority of fluphenazine probably was attributable to improved compliance with the prescribed regimen by patients receiving parenteral depot medication. Despite the advanced age of the subjects, significant adverse drug effects were uncommon.

摘要

将庚酸氟奋乃静通过肠胃外给药与口服抗精神病药物(氟哌啶醇)用于晚发性妄想症老年门诊患者的“危机干预”治疗进行比较。在氟奋乃静组中,13名患者中有11名病情改善,而口服药物组的13名患者中只有3名病情改善(p<0.01)。氟奋乃静的优势可能归因于接受肠胃外长效药物治疗的患者对规定治疗方案的依从性提高。尽管研究对象年龄较大,但显著的药物不良反应并不常见。

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引用本文的文献

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Long-acting injectable antipsychotics in the elderly: guidelines for effective use.老年患者长效注射用抗精神病药物:有效使用指南
Drugs Aging. 2003;20(15):1099-110. doi: 10.2165/00002512-200320150-00003.
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Treatment of schizophrenia and delusional disorder in the elderly.老年人精神分裂症和妄想障碍的治疗。
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