Frigo G M, Del Tacca M, Lecchini S, Crema A
Gut. 1973 Jan;14(1):35-40. doi: 10.1136/gut.14.1.35.
Both at rest and during transmural stimulation acetylcholine output from isolated longitudinal and circular muscle strips is significantly higher in the spastic segment than in the proximal dilated bowel. No difference has been found in the tissue concentration of acetylcholine between ganglionic and aganglionic specimens. The pattern of response to transmural stimulation is also similar in the spastic and dilated bowel. However, after cholinergic and adrenergic blockade transmural stimulation fails to induce relaxation in aganglionic specimens, as it does in normal colon. The hypotheses are advanced that the increase in acetylcholine output may be partly dependent on a failure of the intrinsic modulating mechanisms and that an alteration of the non-adrenergic inhibitory neurons may be involved in the motor disturbances of the aganglionic tract.
在静息状态以及跨壁刺激期间，痉挛段孤立的纵行肌条和环行肌条释放的乙酰胆碱量显著高于近端扩张肠段。神经节标本和无神经节标本的乙酰胆碱组织浓度未发现差异。痉挛肠段和扩张肠段对跨壁刺激的反应模式也相似。然而，与正常结肠不同，在胆碱能和肾上腺素能阻断后，跨壁刺激无法使无神经节标本产生松弛。有人提出假说，乙酰胆碱释放增加可能部分取决于内在调节机制的失效，并且非肾上腺素能抑制神经元的改变可能与无神经节肠段的运动障碍有关。
