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肝素疗法在脑膜炎球菌败血症中的应用

Heparin therapy in meningococcal septicaemia.

作者信息

Hunter J

出版信息

Arch Dis Child. 1973 Mar;48(3):233-5. doi: 10.1136/adc.48.3.233.

DOI:10.1136/adc.48.3.233
PMID:4693465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1648088/
Abstract

Two cases of meningococcaemia with bad prognostic signs are presented. In one child a state of disseminated intravascular coagulation and defibrinogenation was established. Heparin therapy was used early and successfully in both cases, supporting the value of early anticoagulation in the management of severe meningococcal septicaemia.

摘要

本文报告了两例伴有不良预后体征的脑膜炎球菌血症病例。其中一名儿童出现了弥散性血管内凝血和纤维蛋白原溶解状态。两例均早期使用肝素治疗并取得成功，这支持了早期抗凝在严重脑膜炎球菌败血症治疗中的价值。

相似文献

1
Heparin therapy in meningococcal septicaemia.肝素疗法在脑膜炎球菌败血症中的应用
Arch Dis Child. 1973 Mar;48(3):233-5. doi: 10.1136/adc.48.3.233.
2
Heparin for uncontrolled disseminated intravascular coagulation in meningococcal septicaemia.肝素用于治疗脑膜炎球菌败血症中失控的弥散性血管内凝血。
J R Soc Med. 1989 Dec;82(12):762-3. doi: 10.1177/014107688908201220.
3
[Heparin therapy in meningococcal sepsis].
Minerva Pediatr. 1969 Feb 25;21(8):321.
4
Meningococcemia and consumption coagulopathy treated with heparin and dextran 70.肝素和右旋糖酐70治疗的脑膜炎球菌血症和消耗性凝血病
Arch Intern Med. 1971 Jan;127(1):134-6.
5
Fulminant meningococcemia. Heparin therapy and survival rate.
Scand J Infect Dis. 1971;3(2):127-33. doi: 10.3109/inf.1971.3.issue-2.06.
6
Early heparin therapy in 60 children with acute meningococcemia. Relationship between clinical manifestations and coagulation abnormalities.60例急性脑膜炎球菌血症患儿的早期肝素治疗。临床表现与凝血异常之间的关系。
Acta Chir Belg. 1973 Jul;72(4):288-97.
7
[Coagulation disorders in meningococcal sepsis--with particular attention to heparin therapy].[脑膜炎球菌败血症中的凝血障碍——尤其关注肝素治疗]
Ugeskr Laeger. 1975 Apr 28;137(18):982-5.
8
Disseminated intravascular coagulation in patients with meningococcal infection: laboratory diagnosis and prognostic factors.
Scand J Infect Dis. 1978;10(3):187-91. doi: 10.3109/inf.1978.10.issue-3.06.
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Therapy of acute meningococcal infections: early volume expansion and prophylactic low dose heparin.急性脑膜炎球菌感染的治疗：早期扩容及预防性小剂量肝素治疗。
Am J Med Sci. 1972 Dec;264(6):445-55. doi: 10.1097/00000441-197212000-00002.
10
Circulating fibrin in meningococcemia.
J Pediatr. 1973 May;82(5):787-91. doi: 10.1016/s0022-3476(73)80067-8.

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5
Heparin therapy in meningococcal septicaemia.肝素疗法用于治疗脑膜炎球菌败血症。
Arch Dis Child. 1973 Sep;48(9):748. doi: 10.1136/adc.48.9.748.
6
A comparative study of adverse factors in meningococcaemia and meningococcal meningitis.脑膜炎球菌血症和脑膜炎球菌性脑膜炎不良因素的比较研究。
Postgrad Med J. 1979 Nov;55(649):780-3. doi: 10.1136/pgmj.55.649.780.

本文引用的文献

1
[ANTICOAGULANT THERAPY IN PEDIATRICS].[儿科抗凝治疗]
Helv Paediatr Acta. 1964 Aug;19:213-22.
2
Fulminating meningococcemia treated with cortisone; use of blood eosinophil count as a guide to prognosis and treatment.用可的松治疗暴发性脑膜炎球菌血症；用血嗜酸性粒细胞计数作为预后和治疗的指导。
Pediatrics. 1952 Aug;10(2):138-49.
3
An electron miscroscope study of a case of meningococcemia in man.一例人类脑膜炎球菌血症病例的电子显微镜研究。
Am J Dis Child. 1967 Sep;114(3):268-77. doi: 10.1001/archpedi.1967.02090240082005.
4
Factors in the prognosis of meningococcal infection. Review of 63 cases with emphasis on recognition and management of the severely ill patient.
J Pediatr. 1966 Mar;68(3):457-67. doi: 10.1016/s0022-3476(66)80250-0.
5
Care of the critically ill child: endotoxin shock.危重症患儿的护理：内毒素休克
Pediatrics. 1969 Aug;44(2):248-60.
6
Heparin therapy in fulminant meningococcemia.暴发性脑膜炎球菌血症的肝素治疗
J Pediatr. 1969 Sep;75(3):449-53. doi: 10.1016/s0022-3476(69)80272-6.
7
Fatal intravascular consumption coagulopathy in meningococcal sepsis.脑膜炎球菌败血症中的致死性血管内消耗性凝血病
Am J Med. 1969 Jun;46(6):910-8. doi: 10.1016/0002-9343(69)90093-x.
8
Fulminant meningococcemia and disseminated intravascular coagulation.
Arch Intern Med. 1969 Jul;124(1):55-9.
9
Changes in the blood coagulation system associated with septicemia.与败血症相关的血液凝固系统变化。
N Engl J Med. 1968 Oct 17;279(16):851-6. doi: 10.1056/NEJM196810172791603.
10
Disseminated intravascular coagulation and the Waterhouse-Friderichsen syndrome.弥散性血管内凝血与华-佛综合征。
Arch Dis Child. 1971 Oct;46(249):680-5. doi: 10.1136/adc.46.249.680.