Billewicz W Z, Anderson J, Lind T
Br Med J. 1973 Mar 10;1(5853):573-7. doi: 10.1136/bmj.1.5853.573.
A simple numerical index is presented which describes the shape of an oral glucose tolerance response curve and appears to be a measure of the efficiency of homeostatic control. It is unaffected by the laboratory method of glucose estimation, the site of blood sampling, the amount of glucose given, and whether or not the patient has fasted overnight. The index satisfactorily differentiates clinically diabetic from non-diabetic individuals and seems to provide a sensitive method of describing small changes in glucose homeostatic control such as might occur, for example, in pregnancy.
本文提出了一个简单的数值指标，该指标描述了口服葡萄糖耐量反应曲线的形状，似乎是一种衡量稳态控制效率的指标。它不受葡萄糖测定的实验室方法、采血部位、给予的葡萄糖量以及患者是否过夜禁食的影响。该指标能令人满意地将临床糖尿病患者与非糖尿病个体区分开来，并且似乎提供了一种描述葡萄糖稳态控制微小变化（例如在怀孕期间可能发生的变化）的灵敏方法。
