Michaels L, Hyams V J
J Pathol. 1979 May;128(1):29-38. doi: 10.1002/path.1711280106.
Clinical and histological features of 25 cases with amyloid deposits in the respiratory tract are described. The false cord is the commonest single site of such "primary" amyloid involvement. Evidence of extensive involvement and replacement of seromucinous glands by amyloid was seen in each case. Fourteen cases of plasmacytoma with "secondary" amyloid deposits are also described. The nose and nasopharynx were principally involved as with respiratory tract plasmacytomas in general but a similar association of the amyloid with seromucinous glands was also seen. Electron microscopy showed early involvement of the basal lamina of the duct of a seromucinous gland by amyloid in one case. Possible reasons for the association of amyloid precursors in respiratory tract amyloid with seromucinous glands are given.
本文描述了25例呼吸道淀粉样沉积病例的临床和组织学特征。假声带是此类“原发性”淀粉样变最常见的单一受累部位。在每一病例中均可见到淀粉样物质广泛累及并取代浆液黏液腺的证据。本文还描述了14例伴有“继发性”淀粉样沉积的浆细胞瘤。与一般呼吸道浆细胞瘤一样，鼻和鼻咽是主要受累部位，但也可见到淀粉样物质与浆液黏液腺的类似关联。电镜检查显示在一例中淀粉样物质早期累及浆液黏液腺导管的基膜。文中给出了呼吸道淀粉样变中淀粉样前体与浆液黏液腺相关联的可能原因。
