Papadimitriou J M
J Pathol. 1979 Jun;128(2):93-7. doi: 10.1002/path.1711280207.
Peroxidase cytochemistry which differentiates "resident" from "exudate" peritoneal macrophages in guinea pigs, was used in the investigation of the multinucleate giant cells in foreign body granulomas in the peritoneal cavity of guinea pigs. Only a few, small syncytia (two to three nuclei) displayed the cytochemical characteristics of "resident" macrophages. On the other hand, most of the polykarya at the site of inflammation displayed a distribution of peroxidase activity similar to that of "exudate" macrophages. Irrespective of whether peroxidase cytochemistry distinguishes between a distinct type of macrophage or a specific functional stage, the evidence indicates that fusion is much more frequent between macrophages with "exudate" characteristics. Thus, fusion of these latter cells is responsible for the vast majority of multinucleate giant cells in inflammatory sites. In addition, some form of recognition mechanism between macrophages of similar cytochemical characteristics probably also operates since syncytia exhibited characteristics of either "exudate" or "resident" macrophages, but never both.
过氧化物酶细胞化学可区分豚鼠“驻留”和“渗出”性腹腔巨噬细胞，该方法被用于研究豚鼠腹腔异物肉芽肿中的多核巨细胞。只有少数小的多核体（两到三个核）表现出“驻留”巨噬细胞的细胞化学特征。另一方面，炎症部位的大多数多核体显示出与“渗出”巨噬细胞相似的过氧化物酶活性分布。无论过氧化物酶细胞化学区分的是一种独特类型的巨噬细胞还是一个特定的功能阶段，证据都表明具有“渗出”特征的巨噬细胞之间的融合更为频繁。因此，这些后者细胞的融合是炎症部位绝大多数多核巨细胞的原因。此外，由于多核体表现出“渗出”或“驻留”巨噬细胞的特征，但从不同时表现出两者特征，类似细胞化学特征的巨噬细胞之间可能也存在某种形式的识别机制。
