生物膜的机械变形性与红细胞的球形化
Mechanical deformability of biological membranes and the sphering of the erythrocyte.
作者信息
Adams K H
出版信息
Biophys J. 1973 Mar;13(3):209-17. doi: 10.1016/S0006-3495(73)85981-8.
Abstract
Equations of mechanical equilibrium are applied to the erythrocyte membrane in the normal, hypotonically swollen, and sphered configurations. The hydrostatic pressure drop across the normal cell membrane is shown to be zero for all biconcave shapes if the membrane thickness is uniform. This result leads to the conclusion that the membrane tension is uniform and is a function of membrane potential. A two-dimensional fluid film model for the membrane is introduced to describe the unusual deformability of the erythrocyte during sphering in hypotonic solutions. The model predicts a smooth transition from the biconcave shape to a perfect sphere.
摘要
将力学平衡方程应用于正常、低渗肿胀和球形状态下的红细胞膜。如果膜厚度均匀，对于所有双凹形状，正常细胞膜上的静水压降显示为零。这一结果得出结论：膜张力是均匀的，并且是膜电位的函数。引入了一个二维流体膜模型来描述红细胞在低渗溶液中形成球形时异常的变形能力。该模型预测了从双凹形状到完美球形的平滑转变。
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