Merkal R S, Witzel D A
Infect Immun. 1973 Feb;7(2):196-8. doi: 10.1128/iai.7.2.196-198.1973.
Whole blood, white blood cells, plasma, and "febrile plasma" from an artificially hypersensitized bull were transfused, via catheter, into the mesenteric arteries of calves. After 1 to 3 days, the hypersensitivity of each calf was determined by the intra-arterial administration of johnin. Fever and diarrhea followed johnin administration in the calves that had been given whole blood or white blood cells, and diarrhea followed johnin administration in one calf that had been given plasma. Fever and diarrhea developed rapidly in the calves given "febrile plasma." The results provided additional evidence that the fever and diarrhea of bovine Johne's disease are hypersensitivity phenomena which can be successfully transferred to calves and that the febrile response is cell-mediated; evidence that humoral antibody is involved is suggestive but not convincing.
将来自人工致敏公牛的全血、白细胞、血浆和“发热血浆”通过导管输注到小牛的肠系膜动脉中。1至3天后，通过动脉内注射副结核菌素测定每头小牛的超敏反应。接受全血或白细胞的小牛在注射副结核菌素后出现发热和腹泻，接受血浆的一头小牛在注射副结核菌素后出现腹泻。接受“发热血浆”的小牛迅速出现发热和腹泻。这些结果进一步证明，牛副结核病的发热和腹泻是超敏反应现象，可成功转移给小牛，且发热反应是细胞介导的；体液抗体参与其中的证据虽有提示作用，但并不确凿。
