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通过静脉注射牛血清白蛋白在兔子身上诱发发热。

Fever induced in rabbits by intravenous injection of bovine serum albumin.

作者信息

Hattingh J, Laburn H, Mitchell D

出版信息

J Physiol. 1979 May;290(2):69-77. doi: 10.1113/jphysiol.1979.sp012760.

DOI:10.1113/jphysiol.1979.sp012760
PMID:469803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1278824/
Abstract
  1. Bovine serum albumin injected into conscious rabbits produced a dose-dependent fever of short latency and duration of at least 2 1/2 hr. 2. The fever was not due to contamination by other proteins nor due to contamination by bacterial endotoxin. 3. The fever following albumin injection had characteristics similar to endogenous pyrogen fever. 4. Some traditional ways of distinguishing bacterial endotoxin fever from other types of fever need to be reassessed.
摘要
  1. 给清醒的兔子注射牛血清白蛋白会产生潜伏期短且持续时间至少为2.5小时的剂量依赖性发热。2. 这种发热不是由于其他蛋白质的污染，也不是由于细菌内毒素的污染。3. 注射白蛋白后的发热具有与内源性致热原发热相似的特征。4. 一些区分细菌内毒素发热与其他类型发热的传统方法需要重新评估。

相似文献

1
Fever induced in rabbits by intravenous injection of bovine serum albumin.通过静脉注射牛血清白蛋白在兔子身上诱发发热。
J Physiol. 1979 May;290(2):69-77. doi: 10.1113/jphysiol.1979.sp012760.
2
Effects of alpha-melanocyte stimulating hormone on fever caused by endotoxin in rabbits.α-黑素细胞刺激素对家兔内毒素所致发热的影响。
J Physiol. 1991 Sep;441:469-76. doi: 10.1113/jphysiol.1991.sp018762.
3
[Studies on the relationship between the endotoxin induced fever and the antipyretic effect of reserpine in rabbits (author's transl)].家兔内毒素性发热与利血平退热作用关系的研究（作者译）
Nihon Yakurigaku Zasshi. 1979 Sep;75(6):527-33.
4
Fever induced in rabbits by intraventricular injection of rabbit and human serum albumin.通过脑室内注射兔和人血清白蛋白在兔身上诱导发热。
J Physiol. 1987 Sep;390:137-44. doi: 10.1113/jphysiol.1987.sp016690.
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Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood-brain barrier in rabbits.家兔血脑屏障内外双相热诱导的不同机制的证据。
J Physiol. 1987 Feb;383:629-37. doi: 10.1113/jphysiol.1987.sp016433.
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Nutritional state and endotoxin fever of newborn rabbits.新生兔的营养状况与内毒素发热
Acta Physiol Acad Sci Hung. 1979;53(3):279-83.
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Route of administration differentially affects fevers induced by Gram-negative and Gram-positive pyrogens in rabbits.
Exp Physiol. 2002 May;87(3):391-9. doi: 10.1113/eph8702298.
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Response of body temperature and serum iron concentration to repeated pyrogen injection in rabbits.家兔体温和血清铁浓度对重复注射热原的反应。
Pflugers Arch. 1991 Feb;417(6):558-61. doi: 10.1007/BF00372951.
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On the pyrogenic action of intravenous lipid A in rabbits.静脉注射脂多糖A对家兔的致热作用
J Physiol. 1982 Jul;328:361-70. doi: 10.1113/jphysiol.1982.sp014269.
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Studies on the pathogenesis of fever. IX. Characteristics of endogenous serum pyrogen and mechanisms governing its release.发热发病机制的研究。IX. 内源性血清热原的特性及其释放的调控机制。
J Exp Med. 1957 Dec 1;106(6):787-809. doi: 10.1084/jem.106.6.787.

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On the pyrogenic action of intravenous lipid A in rabbits.静脉注射脂多糖A对家兔的致热作用
J Physiol. 1982 Jul;328:361-70. doi: 10.1113/jphysiol.1982.sp014269.
3
Fever induced in rabbits by intraventricular injection of rabbit and human serum albumin.通过脑室内注射兔和人血清白蛋白在兔身上诱导发热。
J Physiol. 1987 Sep;390:137-44. doi: 10.1113/jphysiol.1987.sp016690.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
THE PRESENCE OF ENDOGENOUS PYROGEN IN NORMAL RABBIT TISSUES.正常兔组织中内源性致热原的存在。
J Exp Med. 1965 Jun 1;121(6):1019-38. doi: 10.1084/jem.121.6.1019.
3
Monoamines, pyrogens and cations: their actions on central control of bodytemperature.单胺类、致热原和阳离子：它们对体温中枢控制的作用。
Pharmacol Rev. 1974 Dec;26(4):289-321.
4
Processes to increase the yields of normal serum albumin.提高正常血清白蛋白产量的方法。
Vox Sang. 1977;32(3):182-4. doi: 10.1111/j.1423-0410.1977.tb00623.x.
5
The febrile responses in rabbits and rats to leucocyte pyrogens of different species.家兔和大鼠对不同物种白细胞致热原的发热反应。
J Physiol. 1978 Jun;279:113-20. doi: 10.1113/jphysiol.1978.sp012333.
6
Pyrogen reactions associated with the infusion of normal serum albumin (human).与输注（人）正常血清白蛋白相关的热原反应。
Transfusion. 1978 Jan-Feb;18(1):102-7. doi: 10.1046/j.1537-2995.1978.18178118551.x.
7
Inflammatory effects of endotoxin-like contaminants in commonly used protein preparations.
Science. 1977 Apr 1;196(4285):83-5. doi: 10.1126/science.557238.
8
Filtration removal of endotoxin (pyrogens) in solution in different states of aggregation.不同聚集状态溶液中内毒素（热原）的过滤去除
Appl Environ Microbiol. 1977 Oct;34(4):382-5. doi: 10.1128/aem.34.4.382-385.1977.
9
Neurochemistry of fever.
S Afr J Med Sci. 1976;41(1):23-48.
10
Reduction of pyrogens--application of molecular filtration.热原的去除——分子过滤的应用
J Pharm Pharmacol. 1978 Mar;30(3):198-9. doi: 10.1111/j.2042-7158.1978.tb13202.x.