家兔和大鼠对不同物种白细胞致热原的发热反应。
The febrile responses in rabbits and rats to leucocyte pyrogens of different species.
作者信息
Borsook D, Laburn H, Mitchell D
出版信息
J Physiol. 1978 Jun;279:113-20. doi: 10.1113/jphysiol.1978.sp012333.
Abstract
- We have investigated the effects on body temperature of rats and rabbits of leucocyte pyrogen derived from the blood of rat, rabbit, ox, pig and baboon. 2. In the rabbit intravenous injections (3.5 ml.) of solutions containing leucocyte pyrogen derived from ox, pig and rabbit blood produced fevers with short latencies; no fevers resulted from injections of similar solutions derived from rat or baboon blood. 3. In the rat intraperitoneal injections (2.0 ml.) of solutions containing leucocyte pyrogen derived from ox blood caused a fever, while pig leucocyte pyrogen produced a marked hypothermia. Neither rabbit, baboon, nor rat leucocyte pyrogen had any significant effect on rectal temperature of the rats. 4. Our results show that there is a variability of response in the rat and the rabbit to injection of leucocyte pyrogen of different species; leucocyte pyrogen may be species specific.
摘要
- 我们研究了源自大鼠、兔子、牛、猪和狒狒血液的白细胞热原对大鼠和兔子体温的影响。2. 在兔子身上，静脉注射（3.5毫升）含有源自牛、猪和兔子血液的白细胞热原的溶液会引发潜伏期短的发热；而注射源自大鼠或狒狒血液的类似溶液则不会引起发热。3. 在大鼠身上，腹腔注射（2.0毫升）含有源自牛血液的白细胞热原的溶液会导致发热，而猪白细胞热原则会引起明显的体温过低。兔子、狒狒和大鼠的白细胞热原对大鼠的直肠温度均无显著影响。4. 我们的结果表明，大鼠和兔子对注射不同物种的白细胞热原的反应存在差异；白细胞热原可能具有物种特异性。
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本文引用的文献
1
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J Exp Med. 1963 Mar 1;117(3):349-64. doi: 10.1084/jem.117.3.349.
2
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J Exp Med. 1957 Aug 1;106(2):293-314. doi: 10.1084/jem.106.2.293.
3
Studies on the pathogenesis of fever. VII. Comparative observations on the production of fever by inflammatory exudates in rabbits and dogs.发热的发病机制研究。VII. 家兔和犬炎症渗出物致热的比较观察。
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