关于两种避孕药致突变性的小鼠研究。
Studies in mice on the mutagenicity of two contraceptive drugs.
作者信息
Wallace M E, Badr F M, Badr R S
出版信息
J Med Genet. 1979 Jun;16(3):206-9. doi: 10.1136/jmg.16.3.206.
An experiment is described which tests for visible and invisible mutants in mice treated with four different doses each of the contraceptives Gynanovlar and Lyndiol. The results show that there is no reason to suppose that either substance has an appreciable mutagenic effect, expressed as an increase of antenatal and postnatal lethals or visibles. The substrain CBA/CagCam, used throughout, has an incidence of 0.27% of singly occurring abnormalities, mainly of the appendicular skeleton, which distinguishes it from the parent CBA strain and its axial variation described by Gruneberg (1963).
本文描述了一项实验，该实验检测了用两种避孕药（炔诺酮庚酸酯和炔雌醇甲醚）的四种不同剂量处理过的小鼠中的可见和不可见突变体。结果表明，没有理由认为这两种物质具有明显的诱变作用，即表现为产前和产后致死率或可见突变的增加。整个实验中使用的CBA/CagCam亚系单发性异常的发生率为0.27%，主要是附肢骨骼异常，这使其与亲代CBA品系及其由格鲁内贝格（1963年）描述的轴向变异有所区别。
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