Kabarity A, Mazrooei S
Mutat Res. 1984 Mar;135(3):181-8. doi: 10.1016/0165-1218(84)90119-8.
Anovlar induces a mitodepressive effect, producing abnormal prophases and a considerable number of micronuclei, i.e. Anovlar can produce major cytological abnormalities. On the other hand, Lyndiol induces minor abnormalities leaving the process of mitosis to proceed almost normally. Microgynon 30 did not show any effect on any of the mitotic stages. Our conclusion may offer an explanation for the contradictory results found in the literature upon the cytological effect of oral contraceptives, although the major chemical constitution of all contraceptives used is the same, still there are minor differences in their chemical structure. These minor differences in chemical structure may be the deciding cause whether or not a contraceptive is harmful.
阿诺夫拉尔会诱导有丝分裂抑制效应，产生异常前期和大量微核，也就是说，阿诺夫拉尔会导致严重的细胞学异常。另一方面，林迪奥尔诱导的异常较轻，有丝分裂过程几乎能正常进行。复方炔诺酮片对任何有丝分裂阶段均无影响。我们的结论或许可以解释文献中关于口服避孕药细胞学效应的矛盾结果，尽管所有使用的避孕药主要化学成分相同，但它们的化学结构仍存在细微差异。这些化学结构上的细微差异可能是决定一种避孕药是否有害的关键因素。
