Bernardis L L, Bellinger L L
J Neurosci Res. 1979;4(3):197-203. doi: 10.1002/jnr.490040307.
Weanling rats with ventromedial (VMNL) and dorsomedial (DMNL) hypothalamic lesions and sham-operated controls were maintained up to 198 days after operation. Food intake was measured throughout the experiment and organ weights were recorded at various periods of sacrifice. Comparisons were made between controls and VMNL and DMNL rats, respectively. Food intake and organ weights were expressed in absolute terms and relative to body mass and Kleiber's "metabolic size." VMNL rats were always normophagic and showed lower organ weights, regardless of manner of computation. Rats with DMNL, on the other hand, were absolutely hypophagic but relatively normophagic for considerable periods of time when food intake was referred to body mass. A similar relationship obtained for organ weights. The data fit well with previous results and with a hypothesis that holds that DMNL bring about a "resetting" of some central nervous control system that not only allows the rat so operated to subsist on lower substrate levels but also regulates normal growth in relation to body mass.
对患有腹内侧（VMNL）和背内侧（DMNL）下丘脑损伤的断奶大鼠以及假手术对照组进行术后长达198天的饲养。在整个实验过程中测量食物摄入量，并在不同的处死时期记录器官重量。分别对对照组与VMNL组和DMNL组大鼠进行比较。食物摄入量和器官重量以绝对值表示，并相对于体重和克莱伯的“代谢规模”表示。无论计算方式如何，VMNL组大鼠始终具有正常的摄食能力且器官重量较低。另一方面，DMNL组大鼠绝对摄食减少，但当食物摄入量相对于体重计算时，在相当长的一段时间内相对摄食正常。器官重量也呈现类似的关系。这些数据与先前的结果以及一种假说非常吻合，该假说认为DMNL会导致某些中枢神经控制系统的“重置”，这不仅使接受手术的大鼠能够在较低的底物水平下生存，还能根据体重调节正常生长。
