Bellinger L L, Bernardis L L, Brooks S
J Neurosci Res. 1979;4(3):205-14. doi: 10.1002/jnr.490040308.
The effects of bilateral mescencephalic lesions in the area of the ventral noradrenergic bundle (VNA) were studied in immature and mature female rats. The food intake consumption of the immature lesioned rats did not differ from sham operated controls whether fed a chow or high fat diet. However, after the surgery the body weights of the two groups began to diverge with the immature lesioned rats obtaining a significantly lower body weight. By the end of the study the immature lesioned rats were also significantly shorter than the controls. Both groups showed normal body composition throughout the measurement period. Upon refeeding after a one day fast the immature female rats defended their lower than normal pre-fast body weight. These data are in good agreement with our earlier findings using immature male rats. The mature lesioned animals also showed normal food consumption when fed a chow type diet. However the lesioned animals did show a brief hyperphagia when placed on a high fat diet. Unlike the immature lesioned rats the body weight of these lesioned animals did not differ from their sham operated controls. It is suggested that lesions in the area of the VNA may result in hyperphagia or, in no effects on food intake or body weight as reported by others or normophagia with reduced body weight. Exact lesion placement may be responsible for these divergent findings.
在未成熟和成熟雌性大鼠中研究了腹侧去甲肾上腺素能束（VNA）区域双侧中脑损伤的影响。无论喂食普通饲料还是高脂饮食，未成熟损伤大鼠的食物摄入量与假手术对照组没有差异。然而，手术后两组的体重开始出现差异，未成熟损伤大鼠的体重显著降低。到研究结束时，未成熟损伤大鼠也明显比对照组矮。在整个测量期间，两组的身体组成均正常。禁食一天后重新喂食时，未成熟雌性大鼠维持低于正常禁食前的体重。这些数据与我们早期使用未成熟雄性大鼠的研究结果高度一致。当喂食普通饲料时，成熟损伤动物的食物消耗也正常。然而，当给予高脂饮食时，损伤动物确实出现了短暂的食欲亢进。与未成熟损伤大鼠不同，这些损伤动物的体重与假手术对照组没有差异。有人认为，VNA区域的损伤可能导致食欲亢进，或者如其他人所报道的那样，对食物摄入或体重没有影响，或者导致正常摄食但体重减轻。确切的损伤位置可能是导致这些不同结果的原因。
