Bellinger L L, Bernadis L L
J Neurosci Res. 1976;2(1):47-56. doi: 10.1002/jnr.490020107.
Twenty mature male Sprague-Dawley rats were lesioned in the area of the ascending ventral noradrenergic bundle in the mesencephalon. Nine sham-operated animals served as controls. Food intake between the lesioned and nonlesioned groups was not significantly different except for the first day post surgery. However, body weight of the lesioned group was significantly below that of the controls when measured 15 days after the operation. The lesioned animals weighed significantly less than the controls throughout the rest of the experiment. They also were hypoactive when compared to the sham-operated rats. Control rats and lesioned rats did not differ significantly in deep rectal temperature. It is suggested that the significant decrease in body weight of the lesioned rats in the presence of normophagia may be caused by alterations in the animal's metabolism.
二十只成年雄性斯普拉格-道利大鼠在中脑腹侧去甲肾上腺素能束上行区域受到损伤。九只假手术动物作为对照。除了手术后第一天，损伤组和未损伤组之间的食物摄入量没有显著差异。然而，在手术后15天测量时，损伤组的体重明显低于对照组。在实验的其余时间里，损伤动物的体重明显低于对照组。与假手术大鼠相比，它们也表现出活动减少。对照大鼠和损伤大鼠的直肠深部体温没有显著差异。有人认为，在正常摄食情况下，损伤大鼠体重显著下降可能是由动物新陈代谢的改变引起的。
