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缺氧时大鼠脑内的高能磷酸化合物及一些糖酵解底物

High-energy phosphate compounds and some glycolytic substrates in the rat brain during hypoxia.

作者信息

Broniszewska-Ardelt B, Sikorska M

出版信息

J Neurosci Res. 1979;4(4):261-4. doi: 10.1002/jnr.490040404.

Abstract

The influence of acute and prolonged (with resuscitation) hypoxia, upon some glycolytic substrates and high energy phosphate compounds in the rat brain, was studies. Acute hypoxia decreased the content of glucose and glucose-6-phosphate as well as of high energy phosphate compounds. Stimultaneously, an increase of lactic level was recorded. Some adaptation features could be observed, when 30-minute hypoxia with resuscitation was studied. Brain content of high energy compounds returned to the normal value, while that of glucose increased twice over control. However, the level of lactic acid was still increased.

摘要

研究了急性和长时间(伴有复苏)缺氧对大鼠脑中一些糖酵解底物和高能磷酸化合物的影响。急性缺氧降低了葡萄糖、6-磷酸葡萄糖以及高能磷酸化合物的含量。同时,乳酸水平有所升高。当研究伴有复苏的30分钟缺氧时,可以观察到一些适应特征。高能化合物的脑含量恢复到正常值,而葡萄糖含量比对照组增加了两倍。然而,乳酸水平仍然升高。

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