Blaivas J G, Bhimani G, Labib K B
J Urol. 1979 Sep;122(3):342-7. doi: 10.1016/s0022-5347(17)56397-1.
Urodynamic evaluation was done 45 times on 41 consecutive patients with multiple sclerosis. Bladder symptoms correlated poorly with any single urodynamic finding and, accordingly, a comprehensive evaluation was necessary to define the underlying pathophysiology. Only 63 per cent of the patients with symptoms of urgency, frequency and urge incontinence actually were found to have uninhibited bladder contractions, while 73 per cent of the patients with obstructive symptoms had detrusor areflexia. Six patients (15 per cent) had a marked change in urodynamic findings upon repeat examination either because of a change in symptomatology or poor response to treatment. An additional 6 patients had vesicoureteral reflux. Bladder symptoms in multiple sclerosis patients should serve more to alert the clinician to the need for urodynamic testing than to mandate specific treatment.
对41例连续的多发性硬化症患者进行了45次尿动力学评估。膀胱症状与任何单一的尿动力学检查结果相关性不佳，因此，需要进行全面评估以明确潜在的病理生理学机制。在有尿急、尿频和急迫性尿失禁症状的患者中，仅63%被发现存在膀胱无抑制性收缩，而有梗阻症状的患者中73%存在逼尿肌无反射。6例患者（15%）在重复检查时尿动力学检查结果有显著变化，原因要么是症状改变，要么是对治疗反应不佳。另外6例患者存在膀胱输尿管反流。多发性硬化症患者的膀胱症状更多地应提醒临床医生有进行尿动力学检查的必要，而非直接进行特定治疗。
