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人类胸腺激素分泌的超微结构证据。

Fine structural evidence for hormone secretion by the human thymus.

作者信息

Vetters J M, Macadam R F

出版信息

J Clin Pathol. 1973 Mar;26(3):194-7. doi: 10.1136/jcp.26.3.194.

DOI:10.1136/jcp.26.3.194
PMID:4700501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC477685/
Abstract

The epithelial cells of the Hassall's corpuscles in 11 human thymus glands (nine cases of myasthenia gravis and two glands from patients undergoing surgical correction of congenital heart disease) have been examined by electron microscopy. In every instance the epithelial cells have the cytoplasmic organelle complex necessary for ;export'-type secretory activity and in addition contain large numbers of membrane-limited small spheroidal secretion granules.Hassall's corpuscles are avascular anatomical units and a pericorpuscular zone, at least 50 mum broad, is also without blood vessels. It is therefore suggested that the secretory product(s) of the corpuscular epithelial cells has a purely intrathymic function.

摘要

对11例人类胸腺(9例重症肌无力患者以及2例接受先天性心脏病手术矫正患者的胸腺)中哈氏小体的上皮细胞进行了电子显微镜检查。在每一个实例中,上皮细胞都具有“输出”型分泌活动所需的细胞质细胞器复合体,并且还含有大量膜包被的小球状分泌颗粒。哈氏小体是无血管的解剖单位,至少宽50微米的小体周围区域也没有血管。因此,有人提出小体上皮细胞的分泌产物具有纯粹的胸腺内功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434d/477685/1561c4f71350/jclinpath00113-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434d/477685/90e71233f26c/jclinpath00113-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434d/477685/323551c6b51d/jclinpath00113-0033-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434d/477685/cd1d2f05f533/jclinpath00113-0033-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434d/477685/1561c4f71350/jclinpath00113-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434d/477685/90e71233f26c/jclinpath00113-0033-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434d/477685/323551c6b51d/jclinpath00113-0033-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434d/477685/cd1d2f05f533/jclinpath00113-0033-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/434d/477685/1561c4f71350/jclinpath00113-0034-a.jpg

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Fine structural evidence for hormone secretion by the human thymus.人类胸腺激素分泌的超微结构证据。
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本文引用的文献

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AN ELECTRON MICROSCOPIC STUDY OF THYMIC CORPUSCLES IN THE GUINEA PIG AND THE MOUSE.豚鼠和小鼠胸腺小体的电子显微镜研究
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The thymus in mice of strain 129/J, studied with the electron microscope.用电子显微镜研究了129/J品系小鼠的胸腺。
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胸腺提取物TP-1(胸腺刺激素)处理的小鼠中胸腺分泌活性的反馈抑制
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The epithelial framework of the thymus in normal and pathological conditions. Immunohistochemical demonstration of keratin in an autopsy series.正常及病理状态下胸腺的上皮框架。尸检系列中角蛋白的免疫组织化学显示。
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Comparison of thymic histology with response to thymectomy in myasthenia gravis.重症肌无力胸腺组织学与胸腺切除反应的比较。
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Peptide and amine producing endocrine-like cells in the chicken thymus. A chemical, histochemical and electron microscopic study.
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Giant thymic carcinoid.巨大胸腺类癌
Postgrad Med J. 1991 May;67(787):462-5. doi: 10.1136/pgmj.67.787.462.
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The thymus in hemochromatosis.血色素沉着症中的胸腺。
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9
Ultrastructural studies on erythropoiesis in the avian thymus. I. Description of cell types.鸟类胸腺红细胞生成的超微结构研究。I. 细胞类型的描述。
Cell Tissue Res. 1979 Jun 8;199(1):37-61. doi: 10.1007/BF00237726.
10
The persistent PHA-responsive population in the mouse thymus. II. Recirculatory characteristics and immunological properties.小鼠胸腺中持续对PHA有反应的细胞群体。II. 再循环特征和免疫学特性。
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A lymphocytosis stimulating factor in the plasma of chronic lymphatic leukaemic patients.慢性淋巴细胞白血病患者血浆中的淋巴细胞增多刺激因子。
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The fine structure of the thymus of the fetal and neonatal monkey (Macaca mulatta).胎猴及新生猴(恒河猴)胸腺的精细结构
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[Comparative electron microscopic investigation of entodermal reticulum cells in the thymus of newborn and aged wistar-rats].[新生和老年Wistar大鼠胸腺内胚层网状细胞的比较电子显微镜研究]
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Fine structural evidence for hormone secretion by a human thymic tumour.人类胸腺瘤激素分泌的超微结构证据。
J Clin Pathol. 1969 Jul;22(4):407-9. doi: 10.1136/jcp.22.4.407.
9
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J Immunol. 1972 Apr;108(4):1132-5.