Jedrzejczyk J, Wieckowski J, Rymaszewska T, Barnard E A
Science. 1973 Apr 27;180(4084):406-8. doi: 10.1126/science.180.4084.406.
Individual motor endplates in the skeletal muscles of chickens genetically homozygous for muscular dystrophy have been compared with those in normal chickens. Measurements were made there, by specific autoradiographic techniques, of the numbers of total cholinesterase-like molecules and of acetylcholinesterase molecules. The acetylcholinesterase is distinctly decreased at the endplates in dystrophic muscles. The various data available on these muscles are compatible with the concept that a neural factor which determines the synaptic acetylcholinesterase, along with a number of other characters in the muscle cell, is defective in this disorder.
对患有肌肉萎缩症的纯合基因鸡骨骼肌中的单个运动终板与正常鸡的进行了比较。通过特定的放射自显影技术测量了总胆碱酯酶样分子和乙酰胆碱酯酶分子的数量。在营养不良肌肉的终板处，乙酰胆碱酯酶明显减少。关于这些肌肉的各种现有数据与这样一种概念相符，即决定突触乙酰胆碱酯酶的神经因子以及肌肉细胞中的许多其他特征在这种疾病中存在缺陷。
