Adachi H, Motomatsu K, Yara I
Jpn Circ J. 1979 May;43(5):395-401. doi: 10.1253/jcj.43.395.
We observed previously that allopurinol, which was used for the treatment of gout, had a life saving effect after experiment on traumatic shock rats and hemorrhagic shock rabbits. To evaluate the effect of allopurinol fifteen patients undergoing open heart surgery who were considered to have similar metabolic derangement in shock patient were examined. Allopurinol was given orally 2 mg per kg body weight twice before the start of nitrous oxide, oxygen and halothane anesthesia. In the control group of ten patients who were not treated with allopurinol, serum uric acid increased, the lactate/pyruvate ratio rose and beta-glucuronidase activity increased respectively after open heart surgery as in shock. But the metabolic changes of the fifteen patients pretreated with allopurinol were less significant, although same tendency was observed. The heart beat of all patients except one case in the allopurinol group, started spontaneously after extracorporeal circulation without using DC counter shock. In the control group all patients needed DC counter shock. We concluded that allopurinol was effective in preventing damage of cellular structures and derangements of metabolism of patients undergoing open heart surgery.
我们之前观察到，用于治疗痛风的别嘌醇在对创伤性休克大鼠和失血性休克兔进行实验后具有挽救生命的作用。为评估别嘌醇的效果，我们对15名接受心脏直视手术的患者进行了检查，这些患者被认为在休克患者中具有相似的代谢紊乱情况。在开始一氧化二氮、氧气和氟烷麻醉前，别嘌醇按每千克体重2毫克口服，给药两次。在未用别嘌醇治疗的10名患者组成的对照组中，心脏直视手术后血清尿酸升高、乳酸/丙酮酸比值上升以及β-葡萄糖醛酸酶活性增加，情况与休克时相同。但尽管观察到相同趋势，接受别嘌醇预处理的15名患者的代谢变化较小。别嘌醇组除1例外，所有患者在体外循环后无需使用直流电除颤即可自发恢复心跳。对照组所有患者都需要直流电除颤。我们得出结论，别嘌醇在预防接受心脏直视手术患者的细胞结构损伤和代谢紊乱方面是有效的。
