Teulings F A, Fokkens W, Kaalen J G, van der Werf-Messing B
Br J Cancer. 1973 Apr;27(4):316-22. doi: 10.1038/bjc.1973.38.
The basal concentration of the tryptophan metabolite 3-hydroxyanthranilic acid (3OHA), which has carcinogenic properties, was measured with an enzymatic method of determination which allowed separate measurement of free and conjugated 3OHA. The concentration of free 3OHA in untreated bladder cancer patients was significantly (P <0·001) higher than in a healthy control group, but after local therapy the concentration was significantly lower than before treatment (P <0·01). The concentration of conjugated 3OHA was nearly constant in the three groups. It was concluded that other factors than a genetic determined abnormality might be operating in bladder cancer patients which could lead to an abnormal concentration of 3OHA in their urine.
采用一种酶法测定具有致癌特性的色氨酸代谢物3-羟基邻氨基苯甲酸（3OHA）的基础浓度，该方法可分别测定游离型和结合型3OHA。未经治疗的膀胱癌患者中游离3OHA的浓度显著高于健康对照组（P<0.001），但局部治疗后该浓度显著低于治疗前（P<0.01）。三组中结合型3OHA的浓度几乎保持恒定。得出的结论是，除了基因决定的异常外，膀胱癌患者体内可能还有其他因素起作用，这可能导致其尿液中3OHA浓度异常。
