Shigeta S, Misawa T, Aikawa H, Kondo A
Sangyo Igaku. 1979 Jan;21(1):68-73. doi: 10.1539/joh1959.21.68.
Effects of single exposure to toluene on the operant behavior in rats were studied. The animals, in which the behavioral base line had been established, were exposed to 0, 1,000 and 3,000 ppm of toluene vapor for four hours, and the effects on the behavioral pattern of lever pressing were investigated for one hour after the end of exposure using Sidman avoidance test. 1) Exposure to 0 or 1,000 ppm of toluene did not affect the established operant behavior of the rats. 2) Exposure to 3,000 ppm produced increased responses, shortening of the inter-response-time, and no change in shock counts at the early stage of Sidman avoidance test when compared with those before exposure. 3) The behavioral change indicated here appears to be caused by a temporary breakdown of the established timing of lever pressing. 4) The effect of toluene on the operant behavior was strongest immediately after the aviodance test begun and the behavior recovered in about an hour. From the results of our experiment it can be said that the experimental methods used in this study is useful to evaluate the toxicity of toluene to the central nervous system of the animals.
研究了单次暴露于甲苯对大鼠操作性行为的影响。在已建立行为基线的动物中，使其暴露于0、1000和3000 ppm的甲苯蒸气中4小时，并在暴露结束后使用西德曼回避试验对压杆行为模式的影响进行1小时的研究。1）暴露于0或1000 ppm的甲苯对大鼠已建立的操作性行为没有影响。2）与暴露前相比，暴露于3000 ppm时，在西德曼回避试验早期产生了反应增加、反应间隔时间缩短且电击次数无变化。3）此处所示的行为变化似乎是由已建立的压杆定时的暂时破坏引起的。4）甲苯对操作性行为的影响在回避试验开始后立即最强，且行为在约1小时内恢复。从我们的实验结果可以说，本研究中使用的实验方法对于评估甲苯对动物中枢神经系统的毒性是有用的。
