Shigeta S, Aikawa H, Misawa T, Kondo A
J Toxicol Sci. 1978 Nov;3(4):305-12. doi: 10.2131/jts.3.305.
Effects of single exposure to toluene on Sidman avoidance response in rats were studied. The animals, in which the behavioral base line had been established, were exposed 0, 1,000 and 3,000 ppm of toluene vapor for 4 hours and the effects on the behavioral pattern were investigated using Sidman avoidance test for one hour after the termination of toluene exposure. 1) Exposure to 0 or 1,000 ppm of toluene did not produce marked change on the operant behavior. After the exposure to 3,000 ppm, the animals produced increased responses with shortening of the inter-response-time (IRT) and no changes in shock counts from the beginning to the 50 min. zone of the Sidman avoidance test when compared with those before exposure. The behavioral change indicated here appears to be caused by a temporary breakdown of the established timing of lever pressing. 2) The effect of toluene on the operant behavior was strongest immediately after the termination of the exposure and the behavior recovered in about an hour. This result suggested that toluene is rapidly transfered to and removed from the brain.
研究了单次暴露于甲苯对大鼠西德曼回避反应的影响。在已建立行为基线的动物中，让它们分别暴露于0、1000和3000 ppm的甲苯蒸气中4小时，并在甲苯暴露结束后，使用西德曼回避试验1小时，研究对行为模式的影响。1）暴露于0或1000 ppm的甲苯对操作性行为未产生明显变化。暴露于3000 ppm后，与暴露前相比，动物在西德曼回避试验开始至50分钟时段内，反应次数增加，反应间隔时间（IRT）缩短，电击次数无变化。此处所示的行为变化似乎是由既定的压杆定时暂时中断引起的。2）甲苯对操作性行为的影响在暴露结束后立即最为强烈，且行为在约1小时内恢复。该结果表明，甲苯能迅速进入大脑并从大脑中清除。
