Goel K M, Shanks R A
Arch Dis Child. 1973 May;48(5):337-42. doi: 10.1136/adc.48.5.337.
The subsequent course of ulcerative colitis in 25 children admitted to hospital during the period 1931 to 1971 is reviewed. The period of observation averaged 24 years, ranging from 1 to 41 years. 19 patients showed extracolonic manifestations. 4 patients had a single attack of colitis, and in 19 the disease was of the chronic intermittent type. There was one case each of the acute fulminating and chronic continuous types. Three of 8 patients who had colectomy died postoperatively. One further patient died later of carcinoma of the rectal stump. At follow-up 5 patients (20%) had died and the remaining 20 (80%) were in remission. Although the case for surgery in the treatment of acute fulminating or resistant ulcerative colitis may be clear, that for prophylactic panproctocolectomy while the disease is in remission requires further study.
回顾了1931年至1971年期间收治入院的25例儿童溃疡性结肠炎的后续病程。观察期平均为24年，范围从1年至41年。19例患者出现结肠外表现。4例患者结肠炎仅发作一次，19例患者疾病为慢性间歇性类型。急性暴发型和慢性持续型各有1例。接受结肠切除术的8例患者中有3例术后死亡。另有1例患者后来死于直肠残端癌。随访时，5例患者（20%）死亡，其余20例（80%）处于缓解期。虽然手术治疗急性暴发型或难治性溃疡性结肠炎的理由可能很明确，但对于疾病缓解期进行预防性全直肠结肠切除术的情况仍需进一步研究。
