Kumar P J, Silk D B, Marks R, Clark M L, Dawson A M
Gut. 1973 Apr;14(4):280-3. doi: 10.1136/gut.14.4.280.
The jejunal morphological and functional response to either a gluten-free diet or corticosteroid therapy was studied in six patients with dermatitis herpetiformis. In each treatment group there were two patients with subtotal villous atrophy and one with partial villous atrophys. After treatment, in both groups, morphological improvement was seen in villous and surface cell heights, mucosal thickness, and intraepithelial lymphocyte counts. Jejunal function was assessed using the perfusion technique. Absorption of glucose from a 56 mM solution was shown to improve. Water movement from this solution was in a secretory state in four patients (two in each group) before treatment and moved into the normal absorptive range after treatment. These results further outline the similarity between the mucosal lesion of dermatitis herpetiformis and true coeliac disease.
对6例疱疹样皮炎患者的空肠形态和功能对无麸质饮食或皮质类固醇治疗的反应进行了研究。每个治疗组中有2例患者存在绒毛大部萎缩，1例存在部分绒毛萎缩。治疗后，两组患者的绒毛和表面细胞高度、黏膜厚度及上皮内淋巴细胞计数均有形态学改善。采用灌注技术评估空肠功能。结果显示，56 mM溶液中葡萄糖的吸收得到改善。在治疗前，该溶液中的水分运动在4例患者（每组2例）中处于分泌状态，治疗后进入正常吸收范围。这些结果进一步勾勒出疱疹样皮炎的黏膜病变与真正的乳糜泻之间的相似性。
