Snow I B, Maass A R
Nephron. 1979;23 Suppl 1:15-20. doi: 10.1159/000181662.
Following establishment of steady state plasma concentrations of ticrynafen in the mongrel dog, the intravenous injection of large doses of p-aminohippurate (PAH) or sodium salicylate reduced or blocked the urinary excretion of ticrynafen. In a similar manner, the intravenous administration of ticrynafen reduced the urinary excretion of PAH in preloaded dogs. Since PAH and salicylate are actively secreted by a renal tubular organic anion transport system, these data were interpreted as evidence of an active tubular secretion of ticrynafen. The natriuresis and uricosuria which result from the administration of ticrynafen to the mongrel dog were reduced by PAH and salicylate at doses of these compounds which effectively blocked the secretion of ticrynafen. These results demonstrate that in the dog, the natriuretic and uricosuric activity of ticrynafen results from the presence of ticrynafen in the tubular lumen.
在杂种犬体内建立替克瑞纳芬的稳态血浆浓度后，静脉注射大剂量对氨基马尿酸（PAH）或水杨酸钠可减少或阻断替克瑞纳芬的尿排泄。同样，在预先负荷药物的犬体内静脉注射替克瑞纳芬可减少PAH的尿排泄。由于PAH和水杨酸盐是通过肾小管有机阴离子转运系统进行主动分泌的，这些数据被解释为替克瑞纳芬存在主动肾小管分泌的证据。在给予杂种犬替克瑞纳芬后出现的利钠和尿酸尿现象，在给予能有效阻断替克瑞纳芬分泌剂量的PAH和水杨酸盐时会减弱。这些结果表明，在犬体内，替克瑞纳芬的利钠和尿酸尿活性是由于肾小管腔中存在替克瑞纳芬所致。
