Stote R M, Dubb J W, Familiar R, Erb B, Weiherer S, Alexander F
Nephron. 1979;23 Suppl 1:25-32. doi: 10.1159/000181664.
Studies were performed with ticrynafen (tienilic acid) to determine its natriuretic site of action, detailed electrolyte excretion, and its effect on acid excretion and bicarbonate reabsorption. With 500 and 1,000 mg oral doses under conditions of water diuresis, there was a decrease in free water excretion as osmolar clearance increased. During hydropenia, there was no change in free-water reabsorption as osmolar clearance increased. Maximum sodium excretion reached 5.2% of the filtered load. At 500 mg doses, there was no effect on phosphate excretion; with 1,000 mg doses, there was a reduction in phosphate excretion. During bicarbonate infusion, there was no change in the absolute or percent reabsorption of bicarbonate. After chronic administration of ticrynafen, there was no impairment of excretion of al acute acid load. Uric acid excretion increased at least threefold in all studies. The studies indicate that at 500 and 1,000 mg oral doses, ticrynafen has the characteristics of a diuretic which is active in the cortical diluting segment of the distal nephron.
使用替尼酸进行了多项研究，以确定其利尿作用部位、详细的电解质排泄情况，以及对酸排泄和碳酸氢盐重吸收的影响。在水利尿条件下口服500毫克和1000毫克剂量时，随着渗透清除率增加，自由水排泄减少。在缺水状态下，随着渗透清除率增加，自由水重吸收无变化。最大钠排泄量达到滤过负荷的5.2%。500毫克剂量时，对磷酸盐排泄无影响；1000毫克剂量时，磷酸盐排泄减少。在输注碳酸氢盐期间，碳酸氢盐的绝对重吸收量或重吸收百分比无变化。长期服用替尼酸后，对急性酸负荷的排泄无损害。在所有研究中，尿酸排泄至少增加了三倍。这些研究表明，口服500毫克和1000毫克剂量时，替尼酸具有在远曲小管皮质稀释段起作用的利尿剂特性。
