Annunziato L
Neuroendocrinology. 1979;29(1):66-76. doi: 10.1159/000122906.
The tuberoinfundibular dopaminergic (TIDA) neurons appear to present remarkable differences from the nigrostriatal and mesocortical dopaminergic (DA) systems. The hormonal feedback of prolactin on TIDA neurons differs from the neuronal feedback system operating in the striatum and olfactory tubercles. The uptake of dopamine appears to present the characteristics of a high affinity process in the terminals of the striatum and olfactory tubercle, whereas in the median eminence this process exhibits a much lower affinity. The pharmacological properties of postsynaptic receptors in the different DA pathways appear to be similar. However, the intracellular events which are ultimately manifested as physiological responses to dopamine may be completely different in the postsynaptic cells in the neostriatum and in the lactotrophs of the anterior pituitary. In addition, there is evidence suggesting that dopamine receptors in the anterior pituitary are more sensitive to the actions of agonists and antagonists than are dopamine receptors in the striatum.
结节漏斗多巴胺能（TIDA）神经元似乎与黑质纹状体和中皮质多巴胺能（DA）系统存在显著差异。催乳素对TIDA神经元的激素反馈不同于纹状体和嗅结节中运行的神经元反馈系统。多巴胺的摄取在纹状体和嗅结节的终末表现出高亲和力过程的特征，而在正中隆起，这个过程的亲和力要低得多。不同DA通路中突触后受体的药理特性似乎相似。然而，最终表现为对多巴胺生理反应的细胞内事件在新纹状体的突触后细胞和垂体前叶的催乳细胞中可能完全不同。此外，有证据表明，垂体前叶的多巴胺受体比纹状体中的多巴胺受体对激动剂和拮抗剂的作用更敏感。
