中枢给予心房利钠因子的利尿和利钠作用的多巴胺能机制的证据。
Evidence for a dopaminergic mechanism for the diuretic and natriuretic action of centrally administered atrial natriuretic factor.
作者信息
Israel A, Torres M, Barbella Y
机构信息
Faculty of Pharmacy, Department of Biological Science, Universidad Central de Venezuela, Caracas.
出版信息
Cell Mol Neurobiol. 1989 Sep;9(3):369-78. doi: 10.1007/BF00711416.
Abstract
- Intracerebroventricular (IVT) administration of rat atrial natriuretic factor (ANF) (99-126) to conscious male hydrated rats induces a dose-dependent increase in urine and sodium excretion. The possible involvement of brain dopaminergic system in the IVT-ANF-induced diuresis and natriuresis was evaluated. 2. Central sympathectomy (6-OHDA, 250 micrograms/5 microliters, IVT; 72 and 48 hr before IVT-ANF) inhibited both the diuretic and the natriuretic action of centrally administered ANF, suggesting that in the brain ANF requires the integrity of central noradrenergic and/or dopaminergic systems function for its actions. 3. Intracerebroventricular injection of haloperidol and intragastric administration of domperidone prevent the diuretic and natriuretic response to centrally administered ANF. 4. Our data suggest a neuromodulatory action of ANF within the brain and demonstrate an interaction of the peptide with brain dopaminergic systems.
摘要
- 向清醒的雄性水合大鼠脑室内注射大鼠心房利钠因子（ANF）（99 - 126）可引起尿量和钠排泄呈剂量依赖性增加。评估了脑多巴胺能系统在脑室内注射ANF诱导的利尿和利钠作用中的可能参与情况。2. 中枢交感神经切除术（6 - 羟基多巴胺，250微克/5微升，脑室内注射；在脑室内注射ANF前72小时和48小时）抑制了中枢给予ANF的利尿和利钠作用，表明在脑中ANF发挥作用需要中枢去甲肾上腺素能和/或多巴胺能系统功能的完整性。3. 脑室内注射氟哌啶醇和胃内给予多潘立酮可防止对中枢给予ANF的利尿和利钠反应。4. 我们的数据表明ANF在脑内具有神经调节作用，并证明了该肽与脑多巴胺能系统之间的相互作用。
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