Joffe B I, Segal I, Cooper W
J Neurol Neurosurg Psychiatry. 1973 Jun;36(3):484-5. doi: 10.1136/jnnp.36.3.484.
A 12 year old girl with Friedreich's ataxia, in whom progression from chemical to severe insulin-dependent diabetes mellitus occurred over a two year period, is presented. During the phase of subclinical diabetes her plasma immunoreactive insulin response to oral glucose was markedly increased, but when she became symptomatic gross insulin deficiency had supervened. This report draws attention to the unusual disorders of carbohydrate metabolism and insulin secretion that may occur in a variety of neurological conditions.
本文报告了一名12岁患弗里德赖希共济失调的女孩，其在两年内从化学性糖尿病进展为重度胰岛素依赖型糖尿病。在亚临床糖尿病阶段，她口服葡萄糖后血浆免疫反应性胰岛素反应显著增加，但出现症状时已出现严重胰岛素缺乏。本报告提请注意在各种神经系统疾病中可能发生的异常碳水化合物代谢和胰岛素分泌紊乱。
