Stephenson J L
Biophys J. 1973 Jun;13(6):546-67. doi: 10.1016/S0006-3495(73)86006-0.
The analysis of the central core model of the renal medulla is extended to multisolute systems. It is shown that total solute concentration obeys the same differential equations for core and ascending limb as in a single solute system. Equations are derived for the concentration of individual solutes. Application of these equations to a two solute system shows that a central core system can concentrate with all transport being down a concentration gradient. This analysis applied to the renal medulla shows that mixing of urea from the collecting duct (CD) and salt from the loop of Henle in the central core of the inner medulla contributes to the concentration of urine during antidiuresis. It also sets criteria for completely passive function of the loop in the inner medulla, but whether these are satisfied cannot be determined from present experimental data.
肾髓质中央核心模型的分析扩展到多溶质系统。结果表明，总溶质浓度在核心和升支中遵循与单溶质系统相同的微分方程。推导了单个溶质浓度的方程。将这些方程应用于双溶质系统表明，中央核心系统可以在所有转运都沿着浓度梯度下降的情况下进行浓缩。将该分析应用于肾髓质表明，集合管中的尿素与髓袢中的盐在内髓质中央核心中的混合有助于抗利尿期间尿液的浓缩。它还为内髓质中髓袢的完全被动功能设定了标准，但目前的实验数据无法确定这些标准是否得到满足。
